Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice
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چکیده
منابع مشابه
Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice
The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRLlpr mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRLlpr mice show reduced signs of renal pathogenesis, while other parameters such as mean survival time...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0140173